Vitamin D enhances production of soluble ST2, inhibiting the action of IL-33
نویسندگان
چکیده
منابع مشابه
Vitamin D enhances production of soluble ST2, inhibiting the action of IL-33
In our cohort of patients with severe asthma, the majority receiving very high doses of inhaled or systemic corticosteroids, a blood eosinophil count of greater than 0.45 3 10 cells/L can correctly predict sputum eosinophilia in 9 of 10 cases. We have included only patients with severe asthma in our study, and therefore we believe our results are important because these are the patients who wil...
متن کاملSoluble St2 Blocks Il-33 Signaling in Allergic Airway Inflammation
SOLUBLE ST2 BLOCKS IL-33 SIGNALING IN ALLERGIC AIRWAY INFLAMMATION Hiroko Hayakawa1, Morisada Hayakawa1, Akihiro Kume2, and Shin-ichi Tominaga1 From the 1Department of Biochemistry and 2Division of Genetic Therapeutics, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan Running Title: Suppression of IL-33 signaling by soluble ST2 Address correspondence to: Moris...
متن کاملVitamin D Modulates the Expression of IL-27 and IL-33 in the Central Nervous System in Experimental Autoimmune Encephalomyelitis
Background: It has been reported that vitamin D has broad anti-inflammatory and immunomodulatory effects. Objective: To evaluate the effects of vitamin D on the expression of IL-27 and IL-33 in a model of experimental autoimmune encephalomyelitis (EAE). Methods: EAE was induced in C57BL/6 mice by immunization with myelin oligodendroglial glycoprotein mixed with complete Freund's adjuvant. The m...
متن کاملRole of the IL-33-ST2 axis in sepsis
Sepsis remains a major clinical problem with high morbidity and mortality. As new inflammatory mediators are characterized, it is important to understand their roles in sepsis. Interleukin 33 (IL-33) is a recently described member of the IL-1 family that is widely expressed in cells of barrier tissues. Upon tissue damage, IL-33 is released as an alarmin and activates various types of cells of b...
متن کاملOxidation of the alarmin IL-33 regulates ST2-dependent inflammation
In response to infections and irritants, the respiratory epithelium releases the alarmin interleukin (IL)-33 to elicit a rapid immune response. However, little is known about the regulation of IL-33 following its release. Here we report that the biological activity of IL-33 at its receptor ST2 is rapidly terminated in the extracellular environment by the formation of two disulphide bridges, res...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2015
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2014.09.044